Retina and Responsive and Speedy

I have been looking for a solution to serve both retina and have breaking points for mobile in WordPress. I really am impressed with Cloudinary transformations, and the CDN possibilities.

A) I need a client-side solution, to sever static pages, does this plugin interfere with that?

Note: I don’t mind keeping large ‘reference’ images in my library in case someday I want to back away from Cloudinary, that makes sense. But I don’t have a big library of existing photos that I need to convert also, so this isn’t my reason for choosing this app.

B) I think I can do much of the transformations I need in the urls directly, but I think I need their Jquery for serving different image sizes to different screens according to their site. Can I add the condition arguments in via this plugin, or since you likely know more than I, would it be easier/cleaner to forgo using WP to host any files and just use them as host entirely, figuring out the JS for responsiveness separately?