[Plugin: W3 Total Cache] support multi-site!?

Yes, but do not network activate. Activate separately on each site.

Hey,
I do activate it network and blogs of my wp network now are 404 page!

I deactivate and delete the plugin,
does anybody can help me to solve this?

Picchio.. Eek, that sucks. I almost had that problem.

Some file artifacts in wp-content like db.php and object-cache maybe the problem. rename the. OR reinstall it and try activating on ONE blog to fix it, one at time maybe.

I just had the same problem, 500 error though, I replace my .htaccess with my original and it fixed. Your host may be using a special type of cache already.

MS support is MUCH improved in the next release.