Jetpack does not offer any 2FA functionality,
@kokkieh
Doesn’t Jetpack offer WordPress.com Secure Sign On, which can require Two-Step Authentication?
https://jetpack.com/support/sso/
If you’d like to improve the security of Secure Sign On, you can choose to force Two-Step Authentication when users log in via WordPress.com. Here is the line of code that you’ll need:
add_filter( ‘jetpack_sso_require_two_step’, ‘__return_true’ );
Note: This filter only requires that logging in via WordPress.com requires Two-Step Authentication. If you only return true for this filter, then a user could still log in via the default log in form. If you would like to enforce Two-Step Authentication for your site, you could combine the jetpack_sso_require_two_step filter with the jetpack_remove_login_form filter to force users to log in with WordPress.com and use an account with Two-Step Authentication.