Are many sidebars a problem in performance?

Hello,

I have recently downloaded Content Aware Sidebar and on my magazine website, I have to use a different sidebar for every issue of the magazine (there are about 50 issues). Each sidebar has a different condition to be displayed, for example, issue 1 sidebar is displayed only on posts tagged as issue 1 etc.

My question is, will creating so many conditional sidebars create a problem in the performance of the website?

If so, please suggest an alternative or some best practices.