Cannot run admin

Warning: require_once(/home/turnkeys/public_html/wp-load.php) [function.require-once]: failed to open stream: No such file or directory in /home/turnkeys/public_html/wp-admin/install.php on line 18

Fatal error: require_once() [function.require]: Failed opening required ‘/home/turnkeys/public_html/wp-load.php’ (include_path=’.:/usr/lib/php:/usr/local/lib/php’) in /home/turnkeys/public_html/wp-admin/install.php on line 18