Let’s say this is how your posts are formatted in your Main Index Template:
<?php if (have_posts()) : ?>
<?php while (have_posts()) : the_post(); ?>
<div class="post" id="post-<?php the_ID(); ?>">
<h2><a href="<?php the_permalink() ?>" rel="bookmark" title="Permanent Link to <?php the_title(); ?>"><?php the_title(); ?></a></h2>
</div>
<?php endwhile;else; ?>'
So, each post that comes out will be wrapped by a div of class "post".
Therefore, in your stylesheet, add these to the post div:
.post {
float: left;
width: 200px;
height: 100px;
}’
assuming that your total container (page) width is 400px.
This might or might not be sufficient as it depends from theme to theme.