This happened all the time to me when I used blocks, which is a reason why I don’t use them anymore.
What I found is that if you are to save repeatedly the page, and do that too fast for the wp automatic saving process, then these kind of issues can pop up.
I also found that the issues can pop up just like that, without further interference from a human.
What sometimes, but not always helped me was to re-save the settings in the backend.
Sometimes, I had to remove padding, save, re-add padding and save again.
That resolved the problems in some cases, but in other cases I had to fully rebuild the page or post.
Sometimes it helps to check the code generated (by using code editor instead of visual editor in the blocks interface) as it can show what happened to the padding rules in the code itself, and sometimes you can then fix the issue by correcting the padding value manually, however for that you need to read the code that is generated and can’t use the visual interactions, so it is only something you want to do if you are familiar with at least HTML and CSS (and the new Blocks Code syntax)
I hope re-saving the settings will do it for you!