THAT, is a good question
I don’t have access to test on NGINX, so invite you to try it
WP Roids doesn’t make any database edits except for one scheduled task being registered
It edits .htaccess
too. Those are the only two intrusions it makes
Activate and see is all I can say. If s**t hits fan, simply deactivate and all should be well
Then let me know what happened and I can look to incorporate NGINX…