Recommendations for comic studio…

First thing, I have tons of html/css experience and dabble a little of php stuff. So here goes my question…

I’m researching on WP and several modules and I would like to hear your recommendations for best scenario to utilize WP and list the modules that may meet the comic studio needs:

-blog/news site to promote about us, comic titles/issues, news, characters and other things
-non-store site (we only promo and pitch our comic lineup for potential comic publishers and readers)
-host or link to multiple comic titles and its issues (I’m not sure if I should install second WP host the titles/issues to keep them separate from studio’s blog/news site, use WP MU for each title and its issues, go for a single WP for whole thing or different scenario you think is best option.)

-comic viewer capability with creator comment on each “comic” page (e.g. https://www.zeros2heroes.com/cv/cv.php?comicID=496744&sid=) This site is Flash-based, but I’ll be only going for a html-based comic viewer. I figure I’ll need to develop a “comic viewer” template to meet this need.

Hope I have provided sufficient info and let me know if you have any questions or anything before provide your recommendations.

Appreciate your help and opinion…