simple syntax question: wpdb->prepare()

I have a whole load of values (strings and integers mixed) that I need to insert into separate columns in my database. This is what I have so far:

$keys = "column1, column2, column3, column4,... and so on";
$values = "value1, value2, value3, value4... and so on";

$wpdb->query($wpdb->prepare("INSERT INTO tablename ($keys) VALUES ($values))";

Is this possible, or do I have to create a separate variable for each value and declare each as a ‘%d’ or a ‘%s’ ??