Hi TheKaddu,
please check this IE10 screenshot I made with browsershots.org:
https://browsershots.org/screenshots/f029a29ad5bd83a87279eb231b01288b
As you can see, there are no problems with your menus and the slider / background image looks fine too. I get the same results with other services like netrenderer.de or others.
You are always talking about “a lot of problems” but I can’t reproduce them and there are no other clients reporting these issues and as I said, this theme is used on hundreds of websites.
The only issue I can see is that the image with the pumpkin is displayed too large, this is because it has a size of 400 x 286px which is larger than the supposed thumbnail size of 70 x 53px. If you say that you did already regenerate your thumbnails, than this did not work for this image. I suggest to remove the image and upload it again so the theme can generate the thumbnail size and you should be fine.
@andrew: can you confirm the issues in IE10 like TheKaddu is saying? Especially those regarding the slider and menus? Because I can’t.
Regards
Michael