The best choice is to only use:
Cache Enabler + CDN Enabler + Full Site Cache for KeyCDN
The CDN Enabler only let you to enable cache for CSS, JS and Images, move these resources to another domain, and does not cache the HTML pages.
However, with this plugin (full site cache), almost all content will be cached, so the CSS, JS and Images needn’t have another domain, use more than one domain will be slower, because it will add more delay on TLS connect and resolving DNS.
Cache Enabler, which can reduce the server response time if the page is cached, the cache file will saved on server but not on KeyCDN edge server, but will have a better cache rate. It will have an obvious effect if your server’s performance is bad, or some theme or plugins slows down your website,
