I use MainWP to manage 70+ sites from a single console.
What do *you* mean by manage?
]]>Each of my blogs has its own domain, but these are add-on domains with my web host. Similarly, I thought it may be possible to login to a single Wp-admin panel associated with a primary domain and be able to select which blog I want to customize or update from one menu, rather than logging out and back in depending on the blog I’m updating. However each of my blogs has a unique layout theme so perhaps this is not doable.
]]>This may help:
https://halfelf.org/2011/dont-use-wordpress-multisite/
https://pressable.com/2016/02/11/what-is-wordpress-multisite-and-when-should-you-use-it/
https://www.mooveagency.com/wordpress/7-reasons-use-wordpress-multisite/
https://serverpilot.io/docs/why-you-should-not-use-wordpress-multisite