So all your sites tested are able to reproduce this issue, right? Moreover, you were able to reproduce this issue with ALL your plugins disabled AND the default Twenty Sixteen (or at least one of the default Twenty series) theme, right? And, you have updated at least one of your tested sites to version 4.5, right?
Plus, what it sounds like to me, your Chrome tests have been performed by many people on many different computers, right?
So, basically, you’re saying Google’s Chrome browser is running slower than other browsers when one goes to a default WordPress site, right? Yikes!
Can you give us the URL of one of your sites to try ourselves? Moreover, what other browsers have you tested with AND what was the difference in performance noted?
P.S., I am guessing your specific tests have been performed using the latest browser versions, right?