@flamuren @tableauxadmin lots of people are using both plugins and they do not have problems with them. Based on my testings, the plugins work well together (I have to admit I didn’t test all the possible combinations of all the features from both plugins).
What’s important is to save resources and the plugins have common features. If, for instance, you enable minify CSS/JS in Asset CleanUp, don’t do the same in WP-Optimize and vice-versa. Plenty of the features in WP-Optimize are not interfering with Asset CleanUp. This includes caching, compressed images and database cleaning.
My advice would be to check your pages (e.g. the homepage) after you update the settings in Asset CleanUp or WP-Optimize. If you notice any incompatibility, let me know and I will check it out in order to release a fix.
Also is it safe for a beginner to use this plugin?
Asset CleanUp can break your website if you apply the wrong rules. For instance, if you unload a CSS that you believe you do not need on your homepage, but you actually need it, then your layout might end up broken. That’s the only downside of the plugin in my opinion. While it could help you boost the website’s page speed significantly, it could also break the functionality if you apply the wrong rules. If you are not 100% sure that a CSS/JS is needed on a page, it’s better to keep it loaded. My advice would be go keep testing pages and use “Test Mode” so your visitors won’t be affected. Once you get used with the plugin, you will find it easier to use on pretty much any website. That’s what people are often mentioning in the reviews.