I’ve been having a similar issue…
I’ve had several instances lately where nearly all of the plugins on my site deactivate randomly. This includes plugins like WP eStore and WP Affiliate, Popup Domination, Extra Shortcodes for WP eStore, and about 20 or so more. This has happened 3-4 times now, in the past 3 weeks (roughly).
When it happens, I have to go into WordPress and re-activate all these plugins.During the time they are deactivated people can’t purchase from our site because our cart plugin (WP eStore) is one of the plugins that gets deactivated.
Do you have any ideas?
Thanks!