Hi Sabinou,
At Grist we actually have used a little code-fu to achieve this. What you see in the center column is not actually ‘everything except’ News, but instead everything we mark as ‘Featured’.
We created a special taxonomy ( i.e. categorization system ) that keeps track of which posts are ‘featured’, and then we use WP_Query to get only posts in that taxonomy.
That is probably a little heavy handed for what you need.
The following will get you all posts except for those in categories 12 and 34 for example:
$posts = new WP_Query( ‘cat=-12,-34’ );
From there you can use the examples on the WP_Query page to output the posts as you wish.
You definitely need to know some PHP to accomplish this, but the examples in the wordpress docs will take you pretty far, so just give it a shot!
Hope that helps,
Ben from Grist