devildv

I am having this same issue, only I am not running Slimbox 2 or anything of the sort – in fact, all of my plugins are disabled at the moment. I cannot save the options page – including all of my Amazon information – because when I hit “save options” it takes me to a blank page with “500 Server Error”.

Operating System : Linux
Server : Apache 2.2.14
PHP Version : 5.2.11
MYSQL Version : 5.1.44-log

Any ideas? Mixed Bredie, did you ever resolve your issue? My apache error logs look a lot like yours:
[15-Mar-2010 01:42:20] WordPress database error Duplicate key name 'permalink' for query ALTER TABLE wp_now_reading ADD INDEX permalink (b_nice_author, b_nice_title) made by activate_plugin, do_action, call_user_func_array, nr_install, dbDelta [15-Mar-2010 01:42:20] WordPress database error Duplicate key name 'title' for query ALTER TABLE wp_now_reading ADD INDEX title (b_title) made by activate_plugin, do_action, call_user_func_array, nr_install, dbDelta [15-Mar-2010 01:42:20] WordPress database error Duplicate key name 'author' for query ALTER TABLE wp_now_reading ADD INDEX author (b_author) made by activate_plugin, do_action, call_user_func_array, nr_install, dbDelta [15-Mar-2010 01:42:20] WordPress database error Duplicate key name 'book' for query ALTER TABLE wp_now_reading_books2tags ADD INDEX book (book_id) made by activate_plugin, do_action, call_user_func_array, nr_install, dbDelta [15-Mar-2010 01:42:20] WordPress database error Duplicate key name 'm_key' for query ALTER TABLE wp_now_reading_meta ADD INDEX m_key (m_key) made by activate_plugin, do_action, call_user_func_array, nr_install, dbDelta [15-Mar-2010 01:42:20] WordPress database error Duplicate key name 't_name' for query ALTER TABLE wp_now_reading_tags ADD INDEX t_name (t_name) made by activate_plugin, do_action, call_user_func_array, nr_install, dbDelta