I can confirm the issue: I use Adaptive Images on three different websites, all running on Apache and PHP 5.6. With the latest update (0.6.62), the images all over the websites are broken.
When trying to open one of said images in a new tab, the message “Original image not found or not available” is displayed.
Saving the plugin settings does the trick though, no need to clear the plugin cache on my setup.
All WP installations are in the root folder.