We had this running on a site and then when I upgraded my core WP install it gave me the White Screen of Death.
I found 2 causes of this; one not mentioned here.
1. The WP_CACHE = true value in the wp_config file. If WP Super Cache is misconfigured then this will kill your site. Delete this and it should be back up.
2. If the above didn’t work, check for a closing PHP ?> tag in your wp_config.php file along with white space at the end of it. If there’s white space at the end of your config file it’ll kill your site.
After deleting advanced-cache.php, wp-cache-config.php, the wp-super-cache folder, then installing from afresh, the plugin started working again with no problems.