I’ve got the same problem but I’m using still WordPress 1.5. The difference is that I use some plugins which heavily increase the number of queries used, e.g. Ultimate Tag Warrior. I tried
define(‘DISABLE_CACHE’, true);
but that didn’t changed anything.
The Query Diagnostic shows too that most of the queries are like
SELECT option_value FROM wp_options WHERE option_name = ‘home’ LIMIT 1
Without plugins the query number goes down but it’s still high with around 270 queries.
Any suggestions ?