Thanks for all the responses, good to know I am not alone with this. I have done my fair share of testing too and haven’t come up with anything as of yet.
@ nasca when I check the page source the CDN is still serving content, but I haven’t tried testing any changes to CSS or adding new images (both served from the CDN) as this is now on a live site (I did test the update on my test site, but didn’t spot this in time…).
Regrettably I have had to disable my CDN for now within the plugin and relying only on Cloudflare to keep things up to speed. I will give it a day or two and if there is no fix I will revert to the previous version of W3TC as I am out of ideas on how we might fix this short of an update.