It appears to be a file permission issue, I look at line 21 in wp-setting and do not see any access
[18-Sep-2013 13:22:45 America/Chicago] PHP Warning: require() [function.require]: Unable to access /home/vypyrco/public_html/wp-includes/load.php in /home/vypyrco/public_html/wp-settings.php on line 21
[18-Sep-2013 13:22:45 America/Chicago] PHP Warning: require(/home/vypyrco/public_html/wp-includes/load.php) [function.require]: failed to open stream: Permission denied in /home/vypyrco/public_html/wp-settings.php on line 21
[18-Sep-2013 13:22:45 America/Chicago] PHP Warning: require() [function.require]: Unable to access /home/vypyrco/public_html/wp-includes/load.php in /home/vypyrco/public_html/wp-settings.php on line 21
[18-Sep-2013 13:22:45 America/Chicago] PHP Warning: require(/home/vypyrco/public_html/wp-includes/load.php) [function.require]: failed to open stream: Permission denied in /home/vypyrco/public_html/wp-settings.php on line 21
[18-Sep-2013 13:22:45 America/Chicago] PHP Fatal error: require() [function.require]: Failed opening required ‘/home/vypyrco/public_html/wp-includes/load.php’ (include_path=’.:/usr/lib/php:/usr/local/lib/php’) in /home/vypyrco/public_html/wp-settings.php on line 21