Unable to create directory means that you need to change the permission of the directory to let the web server write to that directory. If you can log into your webserver the command is chmod 777 home/vg001web03/41/48/2934841/leftwichlessons/web/web/uploads/
If not, find the upload directory in your web host control pannel and look for a way to change the permissions so the owner, group, and user can read/write/execute the uploads directory.