If you can enable debugging, by adding the following lines to the wp-config.php:
define(‘WP_DEBUG’, true);
define(‘WP_DEBUG_DISPLAY’, true);
define(‘WP_DEBUG_LOG’, true);
You will see in the screen and/or in wp-contents/debug.log the error.
This can tell us what the issue is.
As the changes in the plugin should only apply to new installs, I suspect you might be low on memory on your site. If that is the case, any plugin deactivation will get your site below the memory limit, an update can cause a memory spike.
If your debug log shows something like:
Fatal error: Allowed memory size of 33554432 bytes exhausted, then you are having a memory issue.
If you post (a part of) the debug log here, or email it to me, I can tell you what the issue is.